Neuro-Oncology: Difference between revisions
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{{NoteBox|secondary}}<strong>Related pages</strong> | |||
* [[Pediatric Neuro Oncology]] | |||
* [[Extrinsic Brain Tumors]] | |||
* [[Skull and Skull Base Tumors]] | |||
* [[Genetic Syndromes of Brain Tumors]] | |||
<hr> | |||
* [[Colloid cysts]] | |||
* [[Hemangioblastoma]] | |||
* [[Schwannoma]]{{NoteBoxEnd}} | |||
= Brain Tumor Frequency = | = Brain Tumor Frequency = | ||
<ul> | <ul> | ||
| Line 18: | Line 27: | ||
* Unclassified (5.6%) | * Unclassified (5.6%) | ||
* Lymphoma and hematopoietic (2.1%) | * Lymphoma and hematopoietic (2.1%) | ||
* Germ cell tumors and cysts (0.4%) | * [[Germ cell tumors]] and cysts (0.4%) | ||
| | | | ||
*[[Meningioma]] (36%) | *[[Meningioma]] (36%) | ||
*Pituitary tumors (15.5%) | *Pituitary tumors (15.5%) | ||
*Glioblastoma multiforme (15.1%) | *[[Glioblastoma]] multiforme (15.1%) | ||
*Nerve sheath tumors (8.1%) | *Nerve sheath tumors (8.1%) | ||
* Diffuse astrocytoma (2.3%) | * [[Diffuse astrocytoma]] (2.3%) | ||
*Primary [[CNS lymphoma]] (2%) | *Primary [[CNS lymphoma]] (2%) | ||
*Ependymal (1.9%) | *Ependymal (1.9%) | ||
*Anaplastic astrocytoma (1.7%) | *Anaplastic [[astrocytoma]] (1.7%) | ||
*Pilocytic astrocytoma (1.4%) | *Pilocytic astrocytoma (1.4%) | ||
*Neuronal and neuronal mixed (1.2%) | *Neuronal and neuronal mixed (1.2%) | ||
| Line 34: | Line 43: | ||
*[[Craniopharyngioma]] (0.8%) | *[[Craniopharyngioma]] (0.8%) | ||
*Anaplastic oligodendroglioma (0.5%) | *Anaplastic oligodendroglioma (0.5%) | ||
|} | |||
= Immunohistochemical staining patterns for nervous system tumor = | |||
<table class="wikitable" width="100%"> | |||
<tr> | |||
<th>Neoplasm</th> | |||
<th>GFAP</th> | |||
<th>CAM5.2</th> | |||
<th>EMA</th> | |||
<th>S-100</th> | |||
<th>CgA</th> | |||
<th>Syn</th> | |||
</tr> | |||
<tr> | |||
<td>[[Oligodendroglioma]]</td> | |||
<td>+</td> | |||
<td rowspan="2">–</td> | |||
<td>–</td> | |||
<td rowspan="4">+</td> | |||
<td rowspan="2">–</td> | |||
<td>0</td> | |||
</tr> | |||
<tr> | |||
<td>[[Ependymoma]]</td> | |||
<td>0</td> | |||
<td rowspan="2">0</td> | |||
<td>–</td> | |||
</tr> | |||
<tr> | |||
<td>Choroid plexus papilloma</td> | |||
<td rowspan="8">-</td> | |||
<td rowspan="5">+</td> | |||
<td>0</td> | |||
<td>+</td> | |||
</tr> | |||
<tr> | |||
<td>[[Chordoma]]</td> | |||
<td rowspan="4">+</td> | |||
<td rowspan="2">-</td> | |||
<td rowspan="2">-</td> | |||
</tr> | |||
<tr> | |||
<td>[[Craniopharyngioma]]</td> | |||
<td rowspan="2">–</td> | |||
</tr> | |||
<tr> | |||
<td>Carcinoma</td> | |||
<td>0</td> | |||
<td>0</td> | |||
</tr> | |||
<tr> | |||
<td>Pituitary adenoma</td> | |||
<td rowspan="3">0</td> | |||
<td rowspan="2">+</td> | |||
<td rowspan="2">+</td> | |||
</tr> | |||
<tr> | |||
<td>Paraganglioma</td> | |||
<td rowspan="2">0</td> | |||
<td>-</td> | |||
</tr> | |||
<tr> | |||
<td>[[Meningioma]]</td> | |||
<td>+</td> | |||
<td rowspan="3">–</td> | |||
<td rowspan="2">-</td> | |||
</tr> | |||
<tr> | |||
<td>Melanoma</td> | |||
<td rowspan="2">–</td> | |||
<td rowspan="2">-</td> | |||
<td>+</td> | |||
</tr> | |||
<tr> | |||
<td>[[Hemangioblastoma]]</td> | |||
<td>0</td> | |||
<td>0</td> | |||
<td>0</td> | |||
</tr> | |||
</table> | |||
= Performance Scales = | = Performance Scales = | ||
Latest revision as of 11:23, 22 May 2024
Related pages
- Pediatric Neuro Oncology
- Extrinsic Brain Tumors
- Skull and Skull Base Tumors
- Genetic Syndromes of Brain Tumors
Brain Tumor Frequency
- MC intracranial tumors: Brain Metastases (just over 50%).
- Incidence of primary brain tumors: approximately 20-30 per 100,000 in adults and 5 per 100,000 in children.
- About one third of primary brain tumors in adults are malignant, whereas they account for two thirds in childhood.
- Frequency of WHO subgroups and specific tumors is given (information not provided in the text).
| Commonest Primary Brain Tumors by WHO Group | Commonest Primary Brain Tumors by Subtype |
|---|---|
|
|
Immunohistochemical staining patterns for nervous system tumor
| Neoplasm | GFAP | CAM5.2 | EMA | S-100 | CgA | Syn |
|---|---|---|---|---|---|---|
| Oligodendroglioma | + | – | – | + | – | 0 |
| Ependymoma | 0 | 0 | – | |||
| Choroid plexus papilloma | - | + | 0 | + | ||
| Chordoma | + | - | - | |||
| Craniopharyngioma | – | |||||
| Carcinoma | 0 | 0 | ||||
| Pituitary adenoma | 0 | + | + | |||
| Paraganglioma | 0 | - | ||||
| Meningioma | + | – | - | |||
| Melanoma | – | - | + | |||
| Hemangioblastoma | 0 | 0 | 0 |
Performance Scales
Karnofsky Performance Scale
| Score | Description |
|---|---|
| 100 | Normal; no complaints, no signs of disease |
| 90 | Capable of normal activity, minor symptoms or signs of disease |
| 80 | Normal activity with some difficulty, some symptoms or signs |
| 70 | Caring for self, not capable of normal activity or work |
| 60 | Requiring some help, can take care of most personal requirements |
| 50 | Requires help often, requires frequent medical care |
| 40 | Disabled, requires special care and help |
| 30 | Severely disabled, hospital admission required but no imminent risk of death |
| 20 | Very ill, urgently requiring admission, requires supportive measures or treatment |
| 10 | Moribund, rapidly progressive fatal disease processes |
| 0 | Dead |
Recursive partitioning analysis (RPA)
| RPA class | Description | Median survival (mos) |
|---|---|---|
| 1 |
|
7 |
| 2 | all others (i.e., not RPA class 1 or 3) | 4 |
| 3 | KPS <70 | 2 |
ECOG Performance Scale
| Score | Description |
|---|---|
| 0 | Asymptomatic (fully active, able to carry on all predisease activities without restriction) |
| 1 | Symptomatic but completely ambulatory (restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature) |
| 2 | Symptomatic, <50% in bed during waking hours (ambulatory and capable of all self-care but unable to carry out any work activities) |
| 3 | Symptomatic, >50% in bed during waking hours, but not bedbound (capable of limited self-care) |
| 4 | Bedbound (completely disabled; cannot carry on any self-care; totally confined to bed or chair) |
| 5 | Dead |