Traumatic Brain Injury: Difference between revisions

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(Created page with " {{NoteBox|secondary}}<strong>Key articles</strong><hr> {| style="border-collapse: collapse; width: 100%;" |- | style="width: 15%; vertical-align: top;" | NASCIS I | style="width: 85%; vertical-align: top;" | Efficacy of high-dose vs. standard-dose steroids in acute SCI ⇒ <span style="background-color:#fff2cc;">no difference in neuro. recovery</span>; <span style="background-color:#ea9999;">high-dose steroids had ↑ early mortality & wound infx rates.</span> <i>(J...")
 
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{{NoteBox|secondary}}<strong>Key articles</strong><hr>
{{NoteBox|secondary}}<strong>Key articles</strong><hr>
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| style="width: 15%; vertical-align: top;" | [[NASCIS I]]
| style="width: 15%; vertical-align: top;" | [[DECRA]]
| style="width: 85%; vertical-align: top;" | Efficacy of high-dose vs. standard-dose steroids in acute SCI ⇒ <span style="background-color:#fff2cc;">no difference in neuro. recovery</span>; <span style="background-color:#ea9999;">high-dose steroids had ↑ early mortality & wound infx rates.</span> <i>(JAMA 1984)</i>
| style="width: 85%; vertical-align: top;" | Efficacy of DC in severe TBI /w refractory ↑ ICP ⇒ <span style="background-color:#fff2cc;">DC ↓ ICP & ↓ ICU stay</span>; <span style="background-color:#ea9999;">assoc. /w worse fnx o/c at 6 mn</span>. <i>(N Engl J Med 2011)</i>
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| style="width: 15%; vertical-align: top;" | [[NASCIS II]]
| style="width: 85%; vertical-align: top;" | Efficacy of high-dose steroids & naloxone in acute SCI ⇒ <span style="background-color:#fff2cc;">high-dose steroids significantly ↑ neuro. recovery if Rx w/i 8 hrs of injury</span>; naloxone showed no significant benefits. <i>(N Engl J Med 1990)</i>
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| style="width: 15%; vertical-align: top;" | [[NASCIS III]]
| style="width: 85%; vertical-align: top;" | Efficacy of 24 hrs vs 48 hrs Rx of steroids and 48 hrs Rx of tirilazad mesylate in acute SCI ⇒ <span style="background-color:#fff2cc;">48 hrs steroids ↑ neuro. recovery for pts Tx 3-8 hrs post-injury</span>, while tirilazad showed no superior benefits. <i>(JAMA 1997)</i>
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[[Category:Neurotrauma]]
[[Category:Neurotrauma]]

Revision as of 04:20, 20 July 2024

Key articles
DECRA Efficacy of DC in severe TBI /w refractory ↑ ICP ⇒ DC ↓ ICP & ↓ ICU stay; assoc. /w worse fnx o/c at 6 mn. (N Engl J Med 2011)