Traumatic Brain Injury: Difference between revisions
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| style="width: 15%; vertical-align: top;" | [[CRASH trial]] | | style="width: 15%; vertical-align: top;" | [[CRASH trial]] | ||
| style="width: 85%; vertical-align: top;" | ✓ effect of early <u>steroids</u> Rx in adults /w <u>TBI</u> ⇒ <span style="background-color:#ea9999;">↑ death</span> compared to placebo. <i>(Lancet 2004)</i> | | style="width: 85%; vertical-align: top;" | ✓ effect of early <u>steroids</u> Rx in adults /w <u>TBI</u> ⇒ <span style="background-color:#ea9999;">↑ death</span> compared to placebo. <i>(Lancet 2004)</i> | ||
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| style="width: 15%; vertical-align: top;" | CRASH-2 | |||
| style="width: 85%; vertical-align: top;" | ✓ the effects of early <u>TXA</u> Rx in TBI pts /w significant haemorrhage ⇒ <span style="background-color:#fff2cc;">↓ mortality & death d/t bleeding</span> w/o ↑ vascular occlusive events <i>(Lancet 2010)</i> | |||
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Revision as of 06:11, 20 July 2024
Key articles
| IMPACT Study | ✓ the value of different prognostic factors in TBI ⇒ the most powerful independent prognostic variables identified were age, GCS motor score, pupil response, and CT finding (Marshall classification), labs (PT & glu) (J Neurotrauma. 2007) |
| CRASH trial | ✓ effect of early steroids Rx in adults /w TBI ⇒ ↑ death compared to placebo. (Lancet 2004) |
| CRASH-2 | ✓ the effects of early TXA Rx in TBI pts /w significant haemorrhage ⇒ ↓ mortality & death d/t bleeding w/o ↑ vascular occlusive events (Lancet 2010) |
| DECRA | Efficacy of DC in severe TBI /w refractory ↑ ICP ⇒ DC ↓ ICP & ↓ ICU stay; assoc. /w worse fnx o/c at 6 mn. (N Engl J Med 2011) |
| RESCUEicp | ✓ effectiveness of DC in pts /w TBI & refractory ↑ ICP ⇒ DC ↓ mortality; ↑ risk of severe disability & vegetative state compared to medical Tx alone. (N Engl J Med 2016) |
| BEST-TRIP | ✓ ICP monitoring in pts /w severe TBI improves o/c ⇒ ICP focused Tx was not better to care based on CT and Px → routine ICP monitoring does not provide additional benefits for pts o/c (N Engl J Med 2012) |