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10:20, 26 July 2024 Fmichael1 talk contribs created page Vagus nerve stimulation (Created page with "= Complications = * Voice change / hoarseness * Throat pain / pharyngitis * Dyspnea * Coughing * Parasthesias * Cardiac complications are rare * Infection * Hardware complications * Injury to the vagus nerve - permanent voice change = Outcomes = * 1 year - 35% median reduction of seizure frequency * 2 years - 43% * Long term - 72% ! * Response varies widely, some achieve seizure freedom, others have no benefit! * Improved alertness * Improved quality of life * Shorter s...") Tag: Visual edit: Switched
10:15, 26 July 2024 Fmichael1 talk contribs created page Category:Functional Neurosurgery (Redirected page to Functional Neurosurgery) Tags: New redirect Visual edit
10:15, 26 July 2024 Fmichael1 talk contribs created page Epilepsy (Created page with "{{NoteBox|secondary}}Related pages * Vagus nerve stimulation {{NoteBoxEnd}} Category:Functional Neurosurgery") Tag: Visual edit: Switched
19:00, 25 July 2024 Fmichael1 talk contribs created page File:MilanConsensus.pdf
19:00, 25 July 2024 Fmichael1 talk contribs uploaded File:MilanConsensus.pdf
18:59, 25 July 2024 Fmichael1 talk contribs created page Milan Consensus (Created page with "== Milan Consensus Conference on Intracranial Pressure Monitoring in Traumatic Brain Injury == === Objective === The Milan Consensus Conference aimed to provide consensus on the practical applications of intracranial pressure (ICP) monitoring in severe adult traumatic brain injury (TBI) by discussing its indications and effectiveness. === Methods === A consensus conference was held on October 5, 2013, in Milan, bringing together neurosurgeons and intensivists with reco...")
08:07, 20 July 2024 Fmichael1 talk contribs created page File:A continuum of TBI biomarkers.jpg
08:07, 20 July 2024 Fmichael1 talk contribs uploaded File:A continuum of TBI biomarkers.jpg
08:02, 20 July 2024 Fmichael1 talk contribs created page File:Screenshot 2024-07-20 at 9.01.41.jpg
08:02, 20 July 2024 Fmichael1 talk contribs uploaded File:Screenshot 2024-07-20 at 9.01.41.jpg
07:55, 20 July 2024 Fmichael1 talk contribs created page Traumatic Brain Injury Biomarkers (Created page with "=== Importance === Biomarkers for TBI are crucial for improving diagnosis, prognosis, treatment, and monitoring of brain injuries, ranging from mild concussions to severe coma. === Clinical Validation === Biomarkers such as Ubiquitin C-terminal hydrolase-L1 (UCH-L1) and Glial Fibrillary Acidic Protein (GFAP) have shown promise in diagnosing TBI. The Banyan BTI test, which measures these biomarkers, received FDA clearance in 2018. === Pathophysiology === Biomarkers refl...")
06:49, 20 July 2024 Fmichael1 talk contribs created page File:TAI-B.jpg
06:49, 20 July 2024 Fmichael1 talk contribs uploaded File:TAI-B.jpg
06:48, 20 July 2024 Fmichael1 talk contribs created page File:TAI-A.jpg
06:48, 20 July 2024 Fmichael1 talk contribs uploaded File:TAI-A.jpg
06:45, 20 July 2024 Fmichael1 talk contribs created page Traumatic Axonal Injury (Created page with "== Traumatic Axonal Injury (TAI) Summary == === Definition and Mechanism === Traumatic axonal injury (TAI), previously known as diffuse axonal injury (DAI), occurs when shearing forces during acceleration or deceleration cause widespread microscopic axonal damage. This injury often results from rotational acceleration of the head, leading to shear, stretching, and compressive strains that deform brain tissue. TAI can occur without impact forces, although head impacts ty...")
06:27, 20 July 2024 Fmichael1 talk contribs created page File:The vicious cycle of head injury.jpg
06:27, 20 July 2024 Fmichael1 talk contribs uploaded File:The vicious cycle of head injury.jpg
06:14, 20 July 2024 Fmichael1 talk contribs created page CRASH-2 (Created page with "== CRASH-2 Trial Summary == === Objective === The CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage 2) trial aimed to assess the effects of early administration of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage. === Methods === * '''Design:''' Multicenter, randomized, placebo-controlled trial. * '''Participants:''' 20,211 adult trauma patients with, or at risk of...") Tag: Visual edit: Switched
06:13, 20 July 2024 Fmichael1 talk contribs created page File:CRASH2.pdf
06:13, 20 July 2024 Fmichael1 talk contribs uploaded File:CRASH2.pdf
06:03, 20 July 2024 Fmichael1 talk contribs created page File:CRASH-trial.pdf
06:03, 20 July 2024 Fmichael1 talk contribs uploaded File:CRASH-trial.pdf
06:01, 20 July 2024 Fmichael1 talk contribs created page CRASH trial (Created page with "== CRASH-1 Trial Summary == === Objective === The CRASH-1 (Corticosteroid Randomisation After Significant Head Injury) trial aimed to determine whether early administration of corticosteroids reduces death and disability in adults with head injury compared to placebo. === Methods === * '''Design:''' Randomised, placebo-controlled trial with centralised and non-centralised randomised concealed allocation. * '''Blinding:''' Clinicians, patients, and data analysts were bl...")
05:30, 20 July 2024 Fmichael1 talk contribs created page File:IMPACT-Results.pdf
05:30, 20 July 2024 Fmichael1 talk contribs uploaded File:IMPACT-Results.pdf
05:29, 20 July 2024 Fmichael1 talk contribs created page File:IMPACT.pdf
05:29, 20 July 2024 Fmichael1 talk contribs uploaded File:IMPACT.pdf
05:29, 20 July 2024 Fmichael1 talk contribs created page IMPACT Study (Created page with "== IMPACT Study Summary == === Objective === The IMPACT (International Mission for Prognosis and Clinical Trial Design in Traumatic Brain Injury) study aimed to improve the prediction of outcomes in patients with traumatic brain injury (TBI) and to enhance clinical trial design for this population. === Methods === * '''Design:''' A comprehensive analysis based on individual patient data from 11 studies, including three observational studies and eight randomized control...")
04:51, 20 July 2024 Fmichael1 talk contribs created page File:BEST-TRIP.pdf
04:51, 20 July 2024 Fmichael1 talk contribs uploaded File:BEST-TRIP.pdf
04:49, 20 July 2024 Fmichael1 talk contribs created page BEST-TRIP (Created page with "== BEST-TRIP Trial Summary == === Objective === The BEST-TRIP (Benchmark Evidence from South American Trials: Treatment of Intracranial Pressure) trial aimed to determine whether intracranial pressure (ICP) monitoring improves outcomes in patients with severe traumatic brain injury. === Methods === * '''Design:''' Multicenter, randomized controlled trial. * '''Participants:''' 324 patients aged 13 years or older with severe traumatic brain injury and treated in ICUs in...")
04:38, 20 July 2024 Fmichael1 talk contribs created page File:RESCUEicp.pdf
04:38, 20 July 2024 Fmichael1 talk contribs uploaded File:RESCUEicp.pdf
04:37, 20 July 2024 Fmichael1 talk contribs created page RESCUEicp (Created page with "== RESCUEicp Trial Summary == === Objective === The RESCUEicp (Randomised Evaluation of Surgery with Craniectomy for Uncontrollable Elevation of Intracranial Pressure) trial aimed to assess the effectiveness of decompressive craniectomy in patients with traumatic brain injury and refractory intracranial hypertension. === Methods === * '''Design:''' Multicenter, randomized controlled trial. * '''Participants:''' 408 patients aged 10 to 65 years with traumatic brain inju...")
04:24, 20 July 2024 Fmichael1 talk contribs created page Category:Traumatic Brain Injury (Redirected page to Traumatic Brain Injury) Tags: New redirect Visual edit
04:23, 20 July 2024 Fmichael1 talk contribs created page DECRA (Created page with "== DECRA Trial Summary == === Objective === The DECRA (Decompressive Craniectomy in Diffuse Traumatic Brain Injury) trial aimed to evaluate whether decompressive craniectomy improves functional outcomes in patients with severe traumatic brain injury and refractory intracranial hypertension. === Methods === * '''Design:''' Multicenter, randomized controlled trial. * '''Participants:''' 155 adults with severe diffuse traumatic brain injury and intracranial hypertension r...") Tag: Visual edit: Switched
04:22, 20 July 2024 Fmichael1 talk contribs created page File:DECRA.pdf
04:22, 20 July 2024 Fmichael1 talk contribs uploaded File:DECRA.pdf
04:15, 20 July 2024 Fmichael1 talk contribs created page TBI (Redirected page to Traumatic Brain Injury) Tags: New redirect Visual edit
04:14, 20 July 2024 Fmichael1 talk contribs created page Traumatic Brain Injury (Created page with " {{NoteBox|secondary}}Key articles<hr> {| style="border-collapse: collapse; width: 100%;" |- | style="width: 15%; vertical-align: top;" | NASCIS I | style="width: 85%; vertical-align: top;" | Efficacy of high-dose vs. standard-dose steroids in acute SCI ⇒ no difference in neuro. recovery; high-dose steroids had ↑ early mortality & wound infx rates. (J...")
03:44, 20 July 2024 Fmichael1 talk contribs created page File:NASICS3.pdf
03:44, 20 July 2024 Fmichael1 talk contribs uploaded File:NASICS3.pdf
03:41, 20 July 2024 Fmichael1 talk contribs created page NASCIS III (Created page with "== NASCIS III Trial Summary == === Objective === The NASCIS III (National Acute Spinal Cord Injury Study III) trial aimed to compare the efficacy of 24-hour and 48-hour administration of methylprednisolone, and 48-hour administration of tirilazad mesylate, in improving neurological recovery in patients with acute spinal cord injury. === Methods === * '''Design:''' Multicenter, double-blind, randomized controlled trial. * '''Participants:''' 499 patients with acute spin...")
03:33, 20 July 2024 Fmichael1 talk contribs created page Spinal Cord Injury (Redirected page to Spine trauma) Tags: New redirect Visual edit
03:31, 20 July 2024 Fmichael1 talk contribs created page File:NASICS2.pdf
03:31, 20 July 2024 Fmichael1 talk contribs uploaded File:NASICS2.pdf
03:30, 20 July 2024 Fmichael1 talk contribs created page NASCIS II (Created page with "== NASCIS II Trial Summary == === Objective === The NASCIS II (National Acute Spinal Cord Injury Study II) trial aimed to evaluate the efficacy of high-dose methylprednisolone and naloxone in improving neurological recovery in patients with acute spinal cord injury. === Methods === * '''Design:''' Multicenter, double-blind, randomized controlled trial. * '''Participants:''' 487 patients with acute spinal cord injury were randomized to receive either high-dose methylpre...")
03:14, 20 July 2024 Fmichael1 talk contribs created page NASCIS I (Created page with "== NASCIS I Trial Summary == === Objective === The NASCIS I (National Acute Spinal Cord Injury Study I) trial aimed to evaluate the efficacy of high-dose versus standard-dose methylprednisolone in improving neurological recovery in patients with acute spinal cord injury. === Methods === * '''Design:''' Multicenter, double-blind, randomized controlled trial. * '''Participants:''' 330 patients with acute spinal cord injury were randomized to receive either a high dose (1...") Tag: Visual edit: Switched
03:13, 20 July 2024 Fmichael1 talk contribs created page File:NASICS1.pdf

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