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• 03:54, 5 March 2024 Fmichael1 talk contribs created page Molecular markers in Gliomas (Created page with "= O(6)-Methylguanine-DNA Methyltransferase (MGMT) = *The O(6)-Methylguanine-DNA Methyltransferase (MGMT) is a <mark>DNA repair enzyme</mark> that counteracts the chemotherapeutic effects of alkylating agents. *Cancer-related methylation of the MGMT promoter region results in less DNA repair activity, including that induced by temozolomide (TMZ). *MGMT promoter methylation in GBM is a prognostic and predictive biomarker indicating response to chemoradiation. *Patients wit...")