Traumatic Brain Injury

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Revision as of 04:14, 20 July 2024 by Fmichael1 (talk | contribs) (Created page with " {{NoteBox|secondary}}<strong>Key articles</strong><hr> {| style="border-collapse: collapse; width: 100%;" |- | style="width: 15%; vertical-align: top;" | NASCIS I | style="width: 85%; vertical-align: top;" | Efficacy of high-dose vs. standard-dose steroids in acute SCI ⇒ <span style="background-color:#fff2cc;">no difference in neuro. recovery</span>; <span style="background-color:#ea9999;">high-dose steroids had ↑ early mortality & wound infx rates.</span> <i>(J...")
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Key articles
NASCIS I Efficacy of high-dose vs. standard-dose steroids in acute SCI ⇒ no difference in neuro. recovery; high-dose steroids had ↑ early mortality & wound infx rates. (JAMA 1984)
NASCIS II Efficacy of high-dose steroids & naloxone in acute SCI ⇒ high-dose steroids significantly ↑ neuro. recovery if Rx w/i 8 hrs of injury; naloxone showed no significant benefits. (N Engl J Med 1990)
NASCIS III Efficacy of 24 hrs vs 48 hrs Rx of steroids and 48 hrs Rx of tirilazad mesylate in acute SCI ⇒ 48 hrs steroids ↑ neuro. recovery for pts Tx 3-8 hrs post-injury, while tirilazad showed no superior benefits. (JAMA 1997)
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