Craniopharyngioma

• • Subtypes of craniopharyngioma**

Adamantinomatous craniopharyngioma

- A craniopharyngioma w/ epithelium that form stellate reticulum, wet karatin and basal pallisades. - Up to 95% of cases of this variant shows CTNNB1 mutations and aberrant nuclear expression of beta- catenin. - Bimodal age distribution: childhood peak age 5–15 years, adult peak age 45–60 years.38

Papillary craniopharyngioma

- A craniopharyngioma w/ papillary features. - Occurs in the supratentorial compartment or 3rd ventricle. - 81–95% of cases show BRAF V600E mutations. - Usually solid, or rarely cystic. - Occurs almost exclusively in adults with a mean age of 40–55 years. Epidemiology