Craniopharyngioma

Subtypes of craniopharyngioma

Adamantinomatous craniopharyngioma

• A craniopharyngioma w/ epithelium that form stellate reticulum, wet keratin and basal palisades.
• Up to 95% of cases of this variant shows CTNNB1 mutations and aberrant nuclear expression of beta- catenin.
• Bimodal age distribution: childhood peak age 5–15 years, adult peak age 45–60 years.38

Papillary craniopharyngioma

• A craniopharyngioma w/ papillary features.
• Occurs in the supratentorial compartment or 3rd ventricle.
• 81–95% of cases show BRAF V600E mutations.
• Usually solid, or rarely cystic.
• Occurs almost exclusively in adults with a mean age of 40–55 years.