Chordoma and Chondrosarcoma

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  • Notochordal tumors
  • characteristic physaliphorous cells (containing intracellular mucin)
  • Physaliphorous cells are distinctive, vacuolated cells on histology that probably represent cytoplasmic mucus vacuoles seen ultrastructurally.

Pathology

Extracellular myxoid matrix (black arrow), Physaliphorous cell - bundant, vacuolated/bubbly cytoplasm (red arrow)
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