Chordoma and Chondrosarcoma

• Notochordal tumors
• characteristic physaliphorous cells (containing intracellular mucin)
• Physaliphorous cells are distinctive, vacuolated cells on histology that probably represent cytoplasmic mucus vacuoles seen ultrastructurally.

Pathology

Extracellular myxoid matrix (black arrow), Physaliphorous cell - bundant, vacuolated/bubbly cytoplasm (red arrow)