Malformations of Cortical Development

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Categories

  • group I: abnormal cell proliferation or apoptosis
  • group II: abnormal neuronal migration
  • group III: abnormal cortical organization
Group Characteristics Conditions
Group I abnormal proliferation of neuronal and glial cells
  • Microcephaly
  • macrocephaly
  • FCDs without and with balloon cells (Taylor dysplasia types IIa and IIb),
  • hemimegalencephaly,
  • tuberous sclerosis,
  • dysembryoplastic neuroepithelial tumors (DNETs), gangliogliomas, gangliocytomas
Group II abnormal neuronal migration
  • Lissencephaly
  • Band Heterotopia
Group III abnormal cortical organization
  • Polymicrogyria,
  • schizencephaly,
  • type I FCDs,
  • mild MCDs
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